Novel Lytic Phages Protect Cells and Mice against Pseudomonas aeruginosa Infection-Reference-Cited by-同舟云学术

Novel Lytic Phages Protect Cells and Mice against Pseudomonas aeruginosa Infection

Published:2021-03-25 Issue:8 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Chen Feng¹,Cheng Xingjun²³⁴,Li Jianbo¹,Yuan Xiefang¹,Huang Xiuhua²³⁴,Lian Mao²³⁴,Li Wenfang²³⁴,Huang Tianfang⁵,Xie Yaliu⁶,Liu Jie²³⁴⁷,Gao Pan²³⁴,Wei Xiawei²³⁴,Wang Zhenling²³⁴^ORCID,Wu Min¹⁸^ORCID

Affiliation:

1. Respiratory Department, Allergy and Immunity Institute, Affiliated Hospital, Southwest Medical University, Luzhou, China

2. State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China

3. Cancer Center, West China Hospital, Sichuan University, Chengdu, China

4. Collaborative Innovation Center of Biotherapy, Chengdu, China

5. Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China

6. Department of Otolaryngology, The Seventh People’s Hospital of Chengdu, Chengdu, China

7. Lab of Infectious Diseases and Vaccines, West China Hospital, Sichuan University, Chengdu, China

8. Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, USA

Abstract

Novel lytic phages isolated from various environmental settings were systematically characterized for their critical genetic traits, morphology structures, host ranges against laboratory strains and clinical multidrug-resistant (MDR) Pseudomonas aeruginosa isolates, and antibacterial capacity both in vitro and in mouse models. First, we characterized the genetic traits and compared them with those of other existing phages.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01832-20

Reference58 articles.

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