CsrA Enhances Cyclic-di-GMP Biosynthesis and Yersinia pestis Biofilm Blockage of the Flea Foregut by Alleviating Hfq-Dependent Repression of the hmsT mRNA-Reference-Cited by-同舟云学术

CsrA Enhances Cyclic-di-GMP Biosynthesis and Yersinia pestis Biofilm Blockage of the Flea Foregut by Alleviating Hfq-Dependent Repression of the hmsT mRNA

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Silva-Rohwer Amelia R.¹,Held Kiara¹,Sagawa Janelle¹,Fernandez Nicolas L.²,Waters Christopher M.²,Vadyvaloo Viveka¹^ORCID

Affiliation:

1. Paul G. Allen School for Global Health, Washington State University, Pullman, Washington, USA

2. Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA

Abstract

Yersinia pestis , the bacterial agent of bubonic plague, produces a c-di-GMP-dependent biofilm-mediated blockage of the flea vector foregut to facilitate its transmission by flea bite. However, the intricate molecular regulatory processes that underlie c-di-GMP-dependent biofilm formation and, thus, biofilm-mediated blockage in response to the nutritional environment of the flea are largely undefined.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01358-21

Reference79 articles.

1. Yersinia pestis--etiologic agent of plague

2. Comparative Ability of Oropsylla montana and Xenopsylla cheopis Fleas to Transmit Yersinia pestis by Two Different Mechanisms

3. “Fleaing” the Plague: Adaptations of Yersinia pestis to Its Insect Vector That Lead to Transmission