Inhibiting Type VI Secretion System Activity with a Biomimetic Peptide Designed To Target the Baseplate Wedge Complex-Reference-Cited by-同舟云学术

Inhibiting Type VI Secretion System Activity with a Biomimetic Peptide Designed To Target the Baseplate Wedge Complex

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Cherrak Y.¹,Filella-Merce I.²³,Schmidt V.¹,Byrne D.⁴,Sgoluppi V.¹,Chaiaheloudjou R.¹,Betzi S.⁵,Morelli X.⁵,Nilges M.²,Pellarin R.²,Durand E.¹⁶^ORCID

Affiliation:

1. Laboratoire d'Ingénierie des Systèmes Macromoléculaires, Institut de Microbiologie de la Méditerranée, UMR7255, Aix-Marseille Université—CNRS, Marseille, France

2. Institut Pasteur, Structural Bioinformatics Unit, Department of Structural Biology and Chemistry, CNRS UMR 3528, C3BI USR 3756, Paris, France

3. Sorbonne Université, Collège Doctoral, ED515—Complexité du Vivant, Paris, France

4. Protein Expression Facility, Institut de Microbiologie de la Méditerranée, FR3479, Aix-Marseille Université—CNRS, Marseille, France

5. CRCM, CNRS, INSERM, Institut Paoli-Calmettes, Aix-Marseille University, Marseille, France

6. Laboratoire d'Ingénierie des Systèmes Macromoléculaires, Institut de Microbiologie de la Méditerranée, UMR7255, INSERM, Marseille, France

Abstract

New therapeutic options are urgently needed to fight drug-resistant and life-threatening infections. In contrast to antibiotics that inhibit the growth pathways of bacteria, the antivirulence strategy is a promising approach to disarm pathogens by interfering with bacterial virulence factors without exerting evolutionary pressure.

Funder

Agence Nationale de la Recherche

European Society of Clinical Microbiology and Infectious Diseases

Fondation pour la Recherche Médicale

Espoir Contre la Mucoviscidose

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01348-21

Reference103 articles.