Inactivation of Transcriptional Regulator FabT Influences Colony Phase Variation of Streptococcus pneumoniae-Reference-Cited by-同舟云学术

Inactivation of Transcriptional Regulator FabT Influences Colony Phase Variation of Streptococcus pneumoniae

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Zhang Jinghui¹,Ye Weijie²,Wu Kaifeng¹³,Xiao Shengnan⁴,Zheng Yuqiang⁴,Shu Zhaoche⁵,Yin Yibing¹,Zhang Xuemei¹

Affiliation:

1. Key Laboratory of Diagnostic Medicine Designated by the Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing, People’s Republic of China

2. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, People’s Republic of China

3. Department of Laboratory Medicine, The Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, People’s Republic of China

4. Department of Medicine Laboratory, Children’s Hospital of Chongqing Medical University Chongqing, People’s Republic of China

5. Department of Blood Transfusion, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China

Abstract

Streptococcus pneumoniae is a major human pathogen, and its virulence factors and especially the capsular polysaccharide have been extensively studied. In addition to virulence components that are present on its cell surface that directly interact with the host, S. pneumoniae undergoes a spontaneous and reversible phase variation that allows survival in different host environments.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01304-21

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