Defects in the Ferroxidase That Participates in the Reductive Iron Assimilation System Results in Hypervirulence in Botrytis Cinerea

Author:

Vasquez-Montaño Esteban12,Hoppe Gustavo12,Vega Andrea2,Olivares-Yañez Consuelo12,Canessa Paulo12ORCID

Affiliation:

1. Centro de Biotecnologia Vegetal, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile

2. Millennium Institute for Integrative Biology (iBio), Santiago, Chile

Abstract

The plant-pathogenic fungus B. cinerea causes enormous economic losses, estimated at anywhere between $10 billion and $100 billion worldwide, under both pre- and postharvest conditions. Here, we present the characterization of a loss-of-function mutant in a component involved in iron acquisition that displays hypervirulence. While in different microbial systems iron uptake mechanisms appear to be critical to achieve full pathogenic potential, we found that the absence of the ferroxidase that is part of the reductive iron assimilation system leads to hypervirulence in this fungus. This is an unusual and rather underrepresented phenotype, which can be modulated by iron levels in the plant and provides an unexpected link between iron acquisition, reactive oxygen species (ROS) production, and pathogenesis in the Botrytis -plant interaction.

Funder

iBIO Institute

MINEDUC | Comisión Nacional de Investigación Científica y Tecnológica

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Reference94 articles.

1. Elad Y, Pertot I, Prado AMC, Stewart A. 2015. Plant hosts of Botrytis, p 413–486. In Fillinger S, Elad Y (ed), Botrytis—the fungus the pathogen and its management in agricultural systems. Springer International Publishing, New York, NY.

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4. Genomic Analysis of the Necrotrophic Fungal Pathogens Sclerotinia sclerotiorum and Botrytis cinerea

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