Impact of Daptomycin Dose Exposure Alone or in Combination with β-Lactams or Rifampin against Vancomycin-Resistant Enterococci in an In Vitro Biofilm Model-Reference-Cited by-同舟云学术

Impact of Daptomycin Dose Exposure Alone or in Combination with β-Lactams or Rifampin against Vancomycin-Resistant Enterococci in an In Vitro Biofilm Model

Published:2020-04-21 Issue:5 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Jahanbakhsh Seyedehameneh¹,Singh Nivedita B.¹,Yim Juwon¹,Kebriaei Razieh¹,Smith Jordan R.¹,Lev Katherine¹,Tran T. T.²,Rose Warren E.²,Arias Cesar A.³⁴⁵,Rybak Michael J.¹⁶

Affiliation:

1. Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA

2. School of Pharmacy and Department of Medicine, University of Wisconsin—Madison, Wisconsin, USA

3. Division of Infectious Diseases and Center for Antimicrobial Resistance and Microbial Genomics, UTHealth McGovern Medical School, Houston, Texas, USA

4. Center for Infectious Diseases, UTHealth School of Public Health, Universidad El Bosque, Bogota, Colombia

5. Molecular Genetics and Antimicrobial Resistance Unit—International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia

6. School of Medicine, Wayne State University, Detroit, Michigan, USA

Abstract

Enterococcus faecium strains are commonly resistant to vancomycin and β-lactams. In addition, E. faecium often causes biofilm-associated infections and these infections are difficult to treat. In this context, we investigated the activity of dosing regimens using daptomycin (DAP) (8, 10, 12, and 14 mg/kg of body weight/day) alone and in combination with ceftaroline (CPT), ampicillin (AMP), ertapenem (ERT), and rifampin (RIF) against 2 clinical strains of biofilm-producing vancomycin-resistant Enterococcus faecium (VREfm), namely, strains S447 and HOU503, in an in vitro biofilm model.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02074-19

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