Effect of Clavulanic Acid on the Minimum Inhibitory Concentration of Benzylpenicillin, Ampicillin, Carbenicillin, or Cephalothin Against Clinical Isolates Resistant to Beta-Lactam Antibiotics

Author:

Dumon L.1,Adriaens P.1,Anné J.1,Eyssen H.1

Affiliation:

1. The Rega Institute, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium

Abstract

The effect of clavulanic acid on the minimum inhibitory concentration of benzylpenicillin, ampicillin, carbenicillin, or cephalothin against 353 clinical isolates of penicillin- and/or cephalothin-resistant strains was estimated.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference7 articles.

1. Naturally-occuring ,B-lactamase inhibitors with antibacterial activity;Brown A. G.;J. Antibiot.,1976

2. Hunter P. A. C. Reading and D. A. Witting. 1978. In vitro and in vivo properties of BRL 14151 a novel betalactam with beta-lactamase-inhibitory properties p. 478-480. In W. Siegenthaler and R. Luthy (ed.) Current Chemotherapy; Proc. 10th Int. Congress Chemother. vol. I. American Society for Microbiology Washington D.C.

3. Sodium clavulanate potentiation ofcephalosporin activity against clinical isolates of cephalothin-resistant KlebsielUa pneumoniae;Jackson R. T.;Antimicrob. Agents Chemother.,1978

4. Combined activity of clavulanic acid and ticarcillin against ticarcillin-resistant, gram-negative bacilli;Paisley J. W.;Antimicrob. Agents Chemother.,1978

5. Clavulanic acid: a betalactamase-inhibiting beta-lactam from Streptomyces clavuligerus;Reading C.;Antimicrob. Agents Chemother.,1977

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