Correlation between Presence of Viable Bacteria and Presence of Endotoxin in Middle-Ear Effusions-Reference-Cited by-同舟云学术

Correlation between Presence of Viable Bacteria and Presence of Endotoxin in Middle-Ear Effusions

Published:1998-11 Issue:11 Volume:36 Page:3417-3419
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Dingman Jeffrey R.¹,Rayner Mark G.²,Mishra Suman³,Zhang Yingze¹,Ehrlich Miles D.¹,Post J. Christopher¹⁴,Ehrlich Garth D.¹⁴

Affiliation:

1. Center for Genomic Sciences1 and

2. Department of Pathology, University of Pittsburgh,2 and

3. Department of Otolaryngology, Eye and Ear Institute, University of Pittsburgh Medical Center,3 Pittsburgh, Pennsylvania 15213

4. Department of Otolaryngology,4 Allegheny University of the Health Sciences, Pittsburgh, Pennsylvania 15212, and

Abstract

ABSTRACT The presence of endotoxin (detected by the Limulus amebocyte lysate assay) was compared to the presence of viable Haemophilus influenzae and Moraxella catarrhalis (detected by PCR) in 106 middle-ear effusions from pediatric patients with chronic otitis media. Endotoxin was found in 81 of the 106 specimens. Of these 81 specimens, 66 (81.5%) also tested positive for one or both of the gram-negative bacteria H. influenzae and M. catarrhalis . The data suggest that viable gram-negative bacteria, detectable by PCR but often undetectable by culture, may be the source of endotoxin in middle-ear effusions.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.36.11.3417-3419.1998

Reference18 articles.

1. Otitis media (burning questions from clinical practice);Bluestone C. D.;Otolaryngol. Head Neck Surg.,1992

2. Bluestone C. D. Klein J. O. Otitis media in infants and children 2nd ed. 1994 Saunders Philadelphia Pa

3. Microbial biofilms;Costerton J. W.;Annu. Rev. Microbiol.,1995

4. Experimental otitis media with effusion following middle-ear inoculation of nonviable H. influenzae;DeMaria T. F.;Ann. Otol. Rhinol. Laryngol.,1984

5. Endotoxin in middle-ear effusions from patients with chronic otitis media with effusion

Cited by 46 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Evidence supportive of a bacterial component in the etiology for Alzheimer’s disease and for a temporal-spatial development of a pathogenic microbiome in the brain;Frontiers in Cellular and Infection Microbiology;2023-09-13

2. The Prevalence and Association of Biofilms With Otitis Media With Effusion: A Systematic Review and Meta-Analysis;Annals of Otology, Rhinology & Laryngology;2023-08-08

3. Evidence for the Existence of a Bacterial Etiology for Alzheimer’s Disease and for a Temporal-Spatial Development of a Pathogenic Microbiome in the Brain;2022-08-29

4. The Formation of Biofilm and Bacteriology in Otitis Media with Effusion in Children: A Prospective Cross-Sectional Study;International Journal of Environmental Research and Public Health;2021-03-30

5. Panel 8: Vaccines and immunology;International Journal of Pediatric Otorhinolaryngology;2020-03