Affiliation:
1. Departments of Pathobiology
2. Medicine, University of Washington, Seattle, Washington 98195
Abstract
ABSTRACT
Spirochetes, including
Treponema denticola
, are implicated in the pathogenesis of periodontal disease. Because
T. denticola
lacks lipopolysaccharides that serve as targets for human β-defensin (hβD) binding, we postulated that
T. denticola
would resist killing by hβD. We showed that
T. denticola
is resistant to hβD-1 and -2. Protease inhibitors did not enhance killing of
T. denticola
by hβD-2, suggesting that degradation of hβD-2 by treponemal proteases is not a major factor in
T. denticola
resistance.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
39 articles.
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