Neisseria lactamica Protects against Experimental Meningococcal Infection-Reference-Cited by-同舟云学术

Neisseria lactamica Protects against Experimental Meningococcal Infection

Published:2002-07 Issue:7 Volume:70 Page:3621-3626
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Oliver Kerry J.¹,Reddin Karen M.¹,Bracegirdle Philippa¹,Hudson Michael J.¹,Borrow Ray²,Feavers Ian M.³,Robinson Andrew¹,Cartwright Keith⁴,Gorringe Andrew R.¹

Affiliation:

1. Centre for Applied Microbiology and Research, Salisbury SP4 0JG

2. Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Manchester M20 2LR

3. National Institute for Biological Standards and Control, South Mimms, Potters Bar EN6 3QG

4. Public Health Laboratory, Gloucestershire Royal Hospital, Gloucester GL1 3NN, United Kingdom

Abstract

ABSTRACT Immunological and epidemiological evidence suggests that the development of natural immunity to meningococcal disease results from colonization of the nasopharynx by commensal Neisseria spp., particularly with N. lactamica . We report here that immunization with N. lactamica killed whole cells, outer membrane vesicles, or outer membrane protein (OMP) pools and protected mice against lethal challenge by a number of diverse serogroup B and C meningococcal isolates in a model of bacteremic infection. Sera raised to N. lactamica killed whole cells, OMPs, or protein pools were found to cross-react with meningococcal isolates of a diverse range of genotypes and phenotypes. The results confirm the potential of N. lactamica to form the basis of a vaccine against meningococcal disease.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.70.7.3621-3626.2002

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