Molecular Cloning of a Vaccine Antigen against Infection with the Larval Stage of Echinococcus multilocularis-Reference-Cited by-同舟云学术

Molecular Cloning of a Vaccine Antigen against Infection with the Larval Stage of Echinococcus multilocularis

Published:2002-07 Issue:7 Volume:70 Page:3969-3972
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Gauci Charles¹,Merli Michael²,Muller Volker²,Chow Conan¹,Yagi Kinpei³,Mackenstedt Ute²,Lightowlers Marshall W.¹

Affiliation:

1. Molecular Parasitology Laboratory, Department of Veterinary Science, The University of Melbourne, Werribee, Victoria, Australia

2. Department of Parasitology, University of Hohenheim, Stuttgart, Germany

3. Biotechnology Division, Hokkaido Institute of Public Health, Sapporo, Hokkaido, Japan

Abstract

ABSTRACT Alveolar and cystic hydatidosis are caused by infection with the larval stages of Echinococcus multilocularis and Echinococcus granulosus , respectively. A host-protective antigen has been identified in E. granulosus . Here we identify the presence of a closely related protein in E. multilocularis , characterize and express a cDNA encoding the antigen (designated EM95), determine the structure of the em 95 gene, and demonstrate that the EM95 recombinant protein can be used to induce significant levels of protection against challenge infection with E. multilocularis eggs in mice.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.70.7.3969-3972.2002

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