Cytokines Induce Indoleamine 2,3-Dioxygenase Expression in Human Atheroma-Associated Cells: Implications for Persistent Chlamydophila pneumoniae Infection-Reference-Cited by-同舟云学术

Cytokines Induce Indoleamine 2,3-Dioxygenase Expression in Human Atheroma-Associated Cells: Implications for Persistent Chlamydophila pneumoniae Infection

Published:2002-07 Issue:7 Volume:70 Page:3959-3961
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Sakash Jessica B.¹²,Byrne Gerald I.³,Lichtman Andrew¹,Libby Peter²

Affiliation:

1. Vascular Research Division Department of Pathology, and

2. Leducq Center for Cardiovascular Research, Brigham and Women's Hospital, Boston, Massachusetts 02115

3. Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin 53706

Abstract

ABSTRACT This study shows that vascular smooth muscle cells express significantly higher levels of gamma interferon-inducible indoleamine 2,3-dioxygenase (IDO) activity than endothelium or mononuclear cells. Since IDO activity is linked to persistent Chlamydophila pneumoniae infection, our results suggest that smooth muscle cells may be an important reservoir of that organism in atherosclerosis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.70.7.3959-3961.2002

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