Multicenter Study of Prevalence of Nontuberculous Mycobacteria in Patients with Cystic Fibrosis in France

Author:

Roux Anne-Laure12,Catherinot Emilie13,Ripoll Fabienne1,Soismier Nathalie1,Macheras Edouard14,Ravilly Sophie5,Bellis Gil6,Vibet Marie-Anne7,Le Roux Evelyne5,Lemonnier Lydie5,Gutierrez Cristina8,Vincent Véronique9,Fauroux Brigitte10,Rottman Martin12,Guillemot Didier71112,Gaillard Jean-Louis124

Affiliation:

1. EA3647, UFR de Médecine Paris Ile-de-France Ouest, Université de Versailles Saint Quentin en Yvelines (UVSQ), Guyancourt, France

2. Laboratoire de Microbiologie, Hôpital Raymond Poincaré, Assistance Publique, Hôpitaux de Paris (AP-HP), Garches, France

3. Service de Pneumologie, Hôpital Foch, Suresnes, France

4. Laboratoire de Microbiologie, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France

5. Association Vaincre La Mucoviscidose, Paris, France

6. Institut National d'Etudes Démographiques, Paris, France

7. INSERM, U 657, Paris, France

8. INSERM, U 629, Institut Pasteur, Lille, France

9. WHO, Geneva, Switzerland

10. Service de Pneumologie Pédiatrique, Hôpital Armand Trousseau, AP-HP, Paris, France

11. PhEMI, Institut Pasteur, Paris, France

12. RISE, UFR de Médecine Paris Ile-de-France Ouest, UVSQ, Guyancourt, France

Abstract

ABSTRACT We performed a multicenter prevalence study of nontuberculous mycobacteria (NTM) involving 1,582 patients (mean age, 18.9 years; male/female ratio, 1.06) with cystic fibrosis in France. The overall NTM prevalence (percentage of patients with at least one positive culture) was 6.6% (104/1,582 patients), with prevalences ranging from 3.7% (in the east of France) to 9.6% (in the greater Paris area). Mycobacterium abscessus complex (MABSC; 50 patients) and Mycobacterium avium complex (MAC; 23 patients) species were the most common NTM, and the only ones associated with fulfillment of the American Thoracic Society bacteriological criteria for NTM lung disease. The “new” species, Mycobacterium bolletii and Mycobacterium massiliense , accounted for 40% of MABSC isolates. MABSC species were isolated at all ages, with a prevalence peak between 11 and 15 years of age (5.8%), while MAC species reached their highest prevalence value among patients over 25 years of age (2.2%).

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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