Imipenem plus Fosfomycin as Salvage Therapy for Vertebral Osteomyelitis

Author:

Nakamura Itaru1,Yamaguchi Tetsuo2ORCID,Aoki Kotaro2ORCID,Miura Yuri1,Sato Satoko1,Fujita Hiroaki1,Watanabe Hidehiro1

Affiliation:

1. Department of Infection Prevention and Control, Tokyo Medical University Hospital, Tokyo, Japan

2. Department of Microbiology and Infectious Diseases, Faculty of Medicine, Toho University, Tokyo, Japan

Abstract

We applied combination antibiotic therapy to treat vertebral osteomyelitis and a psoas abscess caused by glycopeptide-intermediate (MIC, 2 μg/ml) and daptomycin-nonsusceptible (>2 μg/ml) methicillin-resistant Staphylococcus aureus . The Etest synergy test showed the largest synergistic effects for imipenem/cilastatin and fosfomycin. Whole-gene sequencing showed amino acid changes in SA0802, SA1193 ( mprF ), and SA1531 ( ald ).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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