Imipenem plus Fosfomycin as Salvage Therapy for Vertebral Osteomyelitis-Reference-Cited by-同舟云学术

Imipenem plus Fosfomycin as Salvage Therapy for Vertebral Osteomyelitis

Published:2020-12-16 Issue:1 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Nakamura Itaru¹,Yamaguchi Tetsuo²^ORCID,Aoki Kotaro²^ORCID,Miura Yuri¹,Sato Satoko¹,Fujita Hiroaki¹,Watanabe Hidehiro¹

Affiliation:

1. Department of Infection Prevention and Control, Tokyo Medical University Hospital, Tokyo, Japan

2. Department of Microbiology and Infectious Diseases, Faculty of Medicine, Toho University, Tokyo, Japan

Abstract

We applied combination antibiotic therapy to treat vertebral osteomyelitis and a psoas abscess caused by glycopeptide-intermediate (MIC, 2 μg/ml) and daptomycin-nonsusceptible (>2 μg/ml) methicillin-resistant Staphylococcus aureus . The Etest synergy test showed the largest synergistic effects for imipenem/cilastatin and fosfomycin. Whole-gene sequencing showed amino acid changes in SA0802, SA1193 ( mprF ), and SA1531 ( ald ).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01746-20

Reference10 articles.

1. Clinical Practice Guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections in Adults and Children

2. Outcome and Attributable Mortality in Critically Ill Patients With Bacteremia Involving Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus

3. Staphylococcus aureus Native Valve Infective Endocarditis: Report of 566 Episodes from the International Collaboration on Endocarditis Merged Database

4. First case report of vancomycin-intermediate sequence type 72 Staphylococcus aureuswith nonsusceptibility to daptomycin

5. Evolution and Single-Nucleotide Polymorphisms in Methicillin-Resistant Staphylococcus aureus Strains with Reduced Susceptibility to Vancomycin and Daptomycin, Based on Determination of the Complete Genome

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Multidisciplinary Management of Sternal Osteomyelitis Due to Klebsiella aerogenes after Open Heart Surgery in a Patient with Multiple Myeloma: A Case Report and Discussion of the Literature;Microorganisms;2023-11-03

2. Fosfomycin;Comprehensive Pharmacology;2022

3. Inadequate Cerebrospinal Fluid Concentrations of Available Salvage Agents Further Impedes the Optimal Treatment of Multidrug-Resistant Enterococcus faecium Meningitis and Bacteremia;Infectious Disease Reports;2021-09-08

4. Intravenous fosfomycin for the treatment of patients with bone and joint infections: a review;Expert Review of Anti-infective Therapy;2021-07-27

5. Case Commentary: Imipenem/Cilastatin and Fosfomycin for Refractory Methicillin-Resistant Staphylococcus aureus Infection: a Novel Combination Therapy;Antimicrobial Agents and Chemotherapy;2020-12-16