Inhibitor-Resistant Mutants Give Important Insights into Candida albicans ABC Transporter Cdr1 Substrate Specificity and Help Elucidate Efflux Pump Inhibition-Reference-Cited by-同舟云学术

Inhibitor-Resistant Mutants Give Important Insights into Candida albicans ABC Transporter Cdr1 Substrate Specificity and Help Elucidate Efflux Pump Inhibition

Published:2022-01-18 Issue:1 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Niimi Masakazu¹,Niimi Kyoko¹,Tanabe Koichi²,Cannon Richard D.¹^ORCID,Lamping Erwin¹^ORCID

Affiliation:

1. Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand

2. Department of Food Science and Human Nutrition, Faculty of Agriculture, Ryukoku University, Shiga, Japan

Abstract

Overexpression of ATP-binding cassette (ABC) transporters is a major cause of drug resistance in fungal pathogens. Milbemycins, enniatin B, beauvericin, and FK506 are promising leads for broad-spectrum fungal multidrug efflux pump inhibitors.

Funder

Health Science Research Grants for Research on Emerging and Re-emerging Infectious Diseases, Ministry of Health, Labour and Welfare of Japan

Research Program of Emerging and Re-emerging Infectious Diseases, Japan Agency for Medical Research and Development

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01748-21

Reference64 articles.

1. The Role of Eukaryotic and Prokaryotic ABC Transporter Family in Failure of Chemotherapy