Self Antigen Prognostic for Human Immunodeficiency Virus Disease Progression

Abstract

ABSTRACT We have recently found that an extracellular protein, α 1 proteinase inhibitor (α 1 PI; α 1 antitrypsin), is required for in vitro human immunodeficiency virus (HIV) infectivity outcome. We show here in a study of HIV-seropositive patients that decreased viral load is significantly correlated with decreased circulating α 1 PI. In the asymptomatic category of HIV disease, 100% of patients manifest deficient levels of active α 1 PI, a condition known to lead to degenerative lung diseases and a dramatically reduced life span. Further, HIV-associated α 1 PI deficiency is correlated with circulating anti-α 1 PI immunoglobulin G. These results suggest that preventing HIV-associated α 1 PI deficiency may provide a strategic target for preventing HIV-associated pathophysiology.