Serum Immunoglobulin G Antibody Responses to Bordetella pertussis Lipooligosaccharide and B. parapertussis Lipopolysaccharide in Children with Pertussis and Parapertussis

Author:

Trollfors Birger1,Lagergård Teresa2,Taranger John1,Bergfors Elisabet1,Schneerson Rachel3,Robbins John B.3

Affiliation:

1. The Göteborg Pertussis Vaccine Study, The Göteborg Primary Health Care System,1and the

2. Department of Medical Microbiology and Immunology, Göteborg University,2 Göteborg, Sweden, and the

3. National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 208923

Abstract

ABSTRACT Serum immunoglobulin G (IgG) antibodies against the lipooligosaccharide (LOS) of Bordetella pertussis and the lipopolysaccharide (LPS) of Bordetella parapertussis were measured by enzyme-linked immunosorbent assay in paired sera from 40 children with pertussis and 14 with parapertussis. Wide differences in the individual responses were noted. Both anti-LOS and -LPS IgG levels increased significantly in the children with pertussis, as did anti-LPS but not anti-LOS in those with parapertussis.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

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