Immune Suppression as the Etiology of Failure To Detect Anti-HBc Antibodies in Patients with Chronic Hepatitis B Virus Infection-Reference-Cited by-同舟云学术

Immune Suppression as the Etiology of Failure To Detect Anti-HBc Antibodies in Patients with Chronic Hepatitis B Virus Infection

Published:2006-06 Issue:6 Volume:44 Page:2250-2253
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Avettand-Fenoel V.¹,Thabut D.²,Katlama C.³,Poynard T.²,Thibault V.¹

Affiliation:

1. Virology Department, Groupe Hospitalier Pitié-Salpêtrière, Paris, France

2. Hepato-Gastro-Enterology Department, Groupe Hospitalier Pitié-Salpêtrière, Paris, France

3. Infectious Diseases Department, Groupe Hospitalier Pitié-Salpêtrière, Paris, France

Abstract

ABSTRACT A lack of anti-HBc antibodies during chronic hepatitis B virus infection is a serological pattern that is rarely observed. In our series of 39 patients with such a confirmed profile, mutations within the precore/core gene were rarely found and the lack of antibody detection was mostly explained by concurrent immunosuppression and the low sensitivities of the serological assays.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00234-06

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