Author:
Inoue Y,Sato K,Fujii T,Hirai K,Inoue M,Iyobe S,Mitsuhashi S
Abstract
Subunits A and B of DNA gyrase were purified from Pseudomonas aeruginosa PAO1 and its mutant, which was resistant to nalidixic acid. Inhibition tests of DNA gyrases reconstituted with a combination of subunits from the two strains showed that an alteration of subunit A but not subunit B caused bacteria to resist fluoroquinolones.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference29 articles.
1. Effects of norfloxacin on DNA metabolism in Pseudomonas aeruginosa;Benbrook D. M.;Antimicrob. Agents Chemother.,1986
2. Bryan L. E. 1979. Resistance to antimicrobial agents: the general nature of the problem and the basis of resistance p. 219-270. In R. G. Doggett (ed.) Pseudomonas aeruginosa: clinical manifestations of infection and current therapy. Academic Press Inc. New York.
3. DNA gyrase and supercoiling of DNA;Cozzareili N. R.;Science,1980
4. Nalidixic acid resistance: a second genetic character involved in DNA gyrase activity;Geilert M.;Proc. Natl. Acad. Sci. USA,1977
5. DNA gyrase: an enzyme that introduces superhelical turns into DNA;Gellert M.;Proc. Natl. Acad. Sci. USA,1976
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