Effect of calcium on in vitro activity of LY146032 against Clostridium difficile

Author:

Faruki H,Niles A C,Heeren R L,Murray P R

Abstract

The in vitro MICs of LY146032 against 63 isolates of Clostridium difficile tested in Wilkins-Chalgren broth ranged from 0.5 to greater than 32 micrograms/ml, with MICs of 4 and 8 micrograms/ml for 50 and 90% of the isolates, respectively. However, when the test medium was supplemented with physiologic concentrations of calcium, the MIC for 90% of the isolates was reduced to less than or equal to 0.12 microgram/ml.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference3 articles.

1. In vitro activity and mechanism of action of A21978C1, a novel cyclic lipopeptide antibiotic;Eliopoulos G. M.;Antimicrob. Agents Chemother.,1985

2. National Committee for Clinical Laboratory Standards. 1985. M17-P. Alternative methods for antimicrobial susceptibility testing of anaerobic bacteria. National Committee for Clinical Laboratory Standards Villanova Pa.

3. Medium for use in antibiotic susceptibility testing of anaerobic bacteria;Wilkins T. D.;Antimicrob. Agents Chemother.,1976

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