Author:
Sommadossi J P,Carlisle R
Abstract
The effects of 3'-azido-3'-deoxythymidine (AZT) and 9-(1,3-dihydroxy-2-propoxymethyl)guanine on myeloid and erythroid colony-forming cells were studied by clonogenic assays. Both consistently inhibited granulocyte-macrophage CFU (CFU-GM) and erythroid burst-forming units in a dose-dependent fashion. Concentrations of AZT and 9-(1,3-dihydroxy-2-propoxymethyl)guanine required for 50% inhibition of CFU-GM were, respectively, 0.9 +/- 0.1 and 2.7 +/- 0.5 microM; those required for 90% inhibition were, respectively, 34.0 +/- 2.8 and 35.7 +/- 3.6 microM. Erythroid burst-forming units were less sensitive to high concentrations of AZT than were CFU-GM.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference13 articles.
1. Athens J. W. 1970. Neutrophilic granulocyte kinetics and granulocytopoiesis p. 1143-1147. In A. S. Gordon (ed.) Regulation of hematopoiesis. Plenum Publishing Corp. New York.
2. Cheng Y. C. E. S. Huang J. C. Lin E. C. Mar J. S. Pagano G. E. Dutschman and S. P. Grill. 1983. Unique spectrum of activity of 9-[(1 3-dihydroxy-2-propoxy)methyl]-guanine against 454 NOTES
3. Treatment of serious cytomegalovirus infections with 9-(1,3-dihydroxy-2- propoxymethyl) guanine in patients with AIDS and other immunodeficiencies;Collaborative DHPG Treatment Study Group.;N. Engl. J. Med.,1986
4. Stimulatory activity for human pluripotent hemopoietic progenitors produced by a human T-lymphocyte cell line;Fauser A. A.;Stem Cells,1981
5. Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase;Furman P. M.;Proc. Natl. Acad. Sci. USA,1986
Cited by
177 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献