In vitro susceptibility of Rickettsia conorii to ciprofloxacin as determined by suppressing lethality in chicken embryos and by plaque assay-Reference-Cited by-同舟云学术

In vitro susceptibility of Rickettsia conorii to ciprofloxacin as determined by suppressing lethality in chicken embryos and by plaque assay

Published:1986-03 Issue:3 Volume:29 Page:424-425
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Raoult D,Roussellier P,Galicher V,Perez R,Tamalet J

Abstract

We tested the susceptibility of Rickettsia conorii to ciprofloxacin, a new quinolone antibiotic. A final concentration of 1 microgram/g of egg was effective in suppressing chicken embryo lethality, and a concentration of 0.25 micrograms/ml inhibited plaque formation in a plaque assay; however, a concentration of 0.5 microgram/ml was necessary to obtain rickettsiacidal activity. These results support the idea that ciprofloxacin could be of clinical use in treating Mediterranean spotted fever.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.29.3.424

Reference8 articles.

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5. Spicer A. J. M. G. Peacock and J. C. Williams. 1981. Effectiveness of several antibiotics in suppressing chick embryo lethality during experimental infections by Coxiella burnetii Rickettsia typhi and Rickettsia ricketsii p. 375-438. In W. Burgdorfer and R. Anacker (ed.) Rickettsiae and rickettsial diseases. Academic Press Inc. New York.

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