Affiliation:
1. Nelson R. Mandela School of Medicine, University of Natal, Durban, South Africa
2. INSERM U396, Hôpital Saint Louis, Paris, France
3. College of Medicine and Medical Sciences, Arabian Gulf University
4. Bahrain Defence Force Hospital, Riffa, Bahrain
5. Joslin Diabetes Center-Bahrain, Manama
Abstract
ABSTRACT
Whereas the genetic risk for type 1 diabetes is linked to human leukocyte antigen (HLA) class II genes, the HLA association in type 2 (non-insulin-dependent) diabetes is less clear. The association between HLA class II genotypes and type 2 diabetes was examined in adult Bahrainis, an Arab population with a high prevalence of type 2 diabetes. HLA-DRB1* and -DQB1* genotyping of 86 unrelated type 2 diabetes patients (age, 51.6 ± 8.2 years; mean duration of diabetes, 7.7 ± 7.1 years) who had a strong family history of diabetes (52 of 72 versus 0 of 89 for controls,
P
< 0.001) and 89 healthy subjects was done by PCR-sequence-specific priming. DRB1*040101 (0.1221 versus 0.0562,
P
= 0.019) and DRB1*070101 (0.2151 versus 0.0843,
P
< 0.001) were positively associated, while DRB1*110101 (0.0698 versus 0.1461,
P
= 0.014) and DRB1*160101 (0.0640 versus 0.1236,
P
= 0.038) were negatively associated with type 2 diabetes. DRB1*040101-DQB1*0302 (0.069 versus 0.0007;
P
= 0.004), DRB1*070101-DQB1*0201 (0.178 versus 0.0761,
P
= 0.007), DRB1*070101-DQB1*050101 (0.125 versus 0.0310,
P
= 0.002), and DRB1*150101-DQB1*060101 (0.0756 versus 0.0281,
P
= 0.008) were more prevalent among patients, while DRB1*160101-DQB1*050101 (0.0702 versus 0.0349,
P
= 0.05) was more prevalent among controls, conferring disease susceptibility or protection, respectively. In Bahrainis with type 2 diabetes, there is a significant association with select HLA class II genotypes, which were distinct from those in type 1 diabetes.
Publisher
American Society for Microbiology
Subject
Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy
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