Whole-Genome Sequences of Two Borrelia afzelii and Two Borrelia garinii Lyme Disease Agent Isolates

Author:

Casjens Sherwood R.1,Mongodin Emmanuel F.2,Qiu Wei-Gang3,Dunn John J.4,Luft Benjamin J.5,Fraser-Liggett Claire M.2,Schutzer Steve E.6

Affiliation:

1. Department of Pathology, Division of Microbiology and Immunology, University of Utah Medical School, Salt Lake City, Utah 84112

2. Institute for Genome Sciences, University of Maryland, School of Medicine, Department of Microbiology and Immunology, Baltimore, Maryland 21201

3. Department of Biological Sciences, Hunter College of the City University of New York, 695 Park Avenue, New York, New York 10065

4. Biology Department, Brookhaven National Laboratory, Upton, New York 11793

5. Department of Medicine, Health Science Center, Stony Brook University, Stony Brook, New York 11794

6. Department of Medicine, University of Medicine and Dentistry of New Jersey—New Jersey Medical School, Newark, New Jersey 07103

Abstract

ABSTRACT Human Lyme disease is commonly caused by several species of spirochetes in the Borrelia genus. In Eurasia these species are largely Borrelia afzelii , B. garinii , B. burgdorferi , and B. bavariensis sp. nov. Whole-genome sequencing is an excellent tool for investigating and understanding the influence of bacterial diversity on the pathogenesis and etiology of Lyme disease. We report here the whole-genome sequences of four isolates from two of the Borrelia species that cause human Lyme disease, B. afzelii isolates ACA-1 and PKo and B. garinii isolates PBr and Far04.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference13 articles.

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2. A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi

3. Whole Genome Sequence of an Unusual Borrelia burgdorferi Sensu Lato Isolate

4. Comparative genomics of Borrelia burgdorferi, p. 79–95;Casjens S. R.;Molecular biology of spirochetes,2006

5. Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi

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