Effect of Pyrrolnitrin on Electron Transport and Oxidative Phosphorylation in Mitochondria Isolated from Neurospora crassa

Author:

Lambowitz Alan M.1,Slayman Carolyn W.2

Affiliation:

1. Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06510

2. Departments of Physiology and Microbiology, Yale University School of Medicine, New Haven, Connecticut 06510

Abstract

Pyrrolnitrin, at low concentrations, uncouples oxidative phosphorylation in Neurospora mitochondria. At higher concentrations, pyrrolnitrin inhibits electron transport both in the flavine region and through cytochrome oxidase.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference13 articles.

1. Pyrrolnitrin, a new antibiotic substance, produced by Pseudomonas;Arima K.;Agr. Biol. Chem.,1964

2. The respiratory chain and oxidative phosphorylation;Chance B.;Advan. Enzymol.,1956

3. The electron transport components of wild type and poky strains of Neurospora crassa;Lambowitz A. M.;J. Biol. Chem.,1972

4. Electron transport in Neurospora mitochondria: studies on wild type and poky;Lambowitz A. M.;J. Biol. Chem.,1972

5. Oxidative phosphorylation in Neurospora mitochondria: studies on wild type, poky, and chloramphenicol-induced wild type;Lambowitz A. M.;J. Biol. Chem.,1972

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