Affiliation:
1. Lilly Research Laboratories, Indianapolis, Indiana 46206
Abstract
The antifungal activity of pyrrolnitrin, previously shown to be effective against superficial infections, was evaluated against experimental systemic mycoses. Pyrrolnitrin was inhibitory in vitro at <0.78 to 100 μg/ml to
Candida albicans, Cryptococcus neoformans, Blastomyces dermatitidis, Sporotrichum schenckii
, and
Histoplasma capsulatum
. Pyrrolnitrin activity was reduced about 90% in sera. After multiple subcutaneous doses of pyrrolnitrin at 20 mg/kg, activity was recovered in mouse blood and urine as well as kidney, liver, and brain homogenates. Multiple daily doses (50 mg/kg) of this antibiotic were effective in reducing by 74% the number of viable cells of
C. albicans
recovered from kidney homogenates. Multiple doses (15 mg/kg) resulted in a 74% reduction in the number of
C. neoformans
from brain homogenates. Pyrrolnitrin was ineffective in reducing the recovery of
B. dermatitidis
or
H. capsulatum
from liver or spleen homogenates of infected mice. When compared with amphotericin B, hamycin, 5-fluorocytosine, and saramycetin, this antibiotic was less effective. This study indicates that pyrrolnitrin would have limited usefulness as a systemic antifungal agent.
Publisher
American Society for Microbiology
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference8 articles.
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5. Observations on the activity of two newer antifungal agents saramycetin (X-5079C) and 5-fluorocytosine. 5th;Grunberg E.;Int. Congr. Chemother. Proc., p.,1967
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