Comparative Roles of the Cell Wall and Cell Membrane in Limiting Uptake of Xenobiotic Molecules by Saccharomyces cerevisiae-Reference-Cited by-同舟云学术

Comparative Roles of the Cell Wall and Cell Membrane in Limiting Uptake of Xenobiotic Molecules by Saccharomyces cerevisiae

Published:2003-06 Issue:6 Volume:47 Page:2012-2014
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Aouida Mustapha¹²,Tounekti Omar²,Belhadj Omrane²,Mir Lluis M.¹

Affiliation:

1. Laboratoire Vectorologie et Transfert de Gènes, UMR 8121 CNRS, Institut Gustave-Roussy, 94805 Villejuif Cédex, France

2. Laboratoire de Biochimie et Technobiologie, Faculté des Sciences de Tunis, Campus Universitaire, 1060 Tunis, Tunisia

Abstract

ABSTRACT Using reversible electropermeabilization of cells and spheroplasts, we show that the cell wall and plasma membrane partly account for bleomycin resistance by acting as two independent barriers. We also report on the presence of a membrane protein that may be responsible for bleomycin internalization and toxicity in Saccharomyces cerevisiae .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.47.6.2012-2014.2003

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