Emergence of Resistance in Normal Human Aerobic Commensal Flora during Telithromycin and Amoxicillin-Clavulanic Acid Treatments-Reference-Cited by-同舟云学术

Emergence of Resistance in Normal Human Aerobic Commensal Flora during Telithromycin and Amoxicillin-Clavulanic Acid Treatments

Published:2003-06 Issue:6 Volume:47 Page:2030-2035
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Crémieux Anne-Claude¹,Muller-Serieys Claudette²,Panhard Xavière³,Delatour Frédérique¹,Tchimichkian Marina⁴,Mentre France³,Andremont Antoine²

Affiliation:

1. Clinical Investigation Center

2. Laboratory of Bacteriology, EMI-U 9933

3. Department of Epidemiology and Biostatistics, Bichat-Claude Bernard Hospital

4. Microbiology Laboratory, Ambroise-Paré Hospital, Paris, France

Abstract

ABSTRACT Mean fecal global yeast counts increased similarly during 7 days of treatment with telithromycin (800 mg once daily) or amoxicillin-clavulanic acid (amoxiclav) (1 g of amoxicillin and 125 mg of clavulanic acid 3 times daily) in human volunteers and decreased slowly thereafter. On skin, coagulase-negative staphylococci of decreased susceptibility (DS) to telithromycin increased in the telithromycin group, whereas those with DS to methicillin increased in the amoxiclav group. A similar antibiotic-related shift towards homologous DS was observed for oral nongroupable streptococci (NGS), but in addition, the prevalence of NGS resistant to both classes of antibiotics was significantly greater in the amoxiclav group at days 8 ( P < 0.01) and 45 ( P < 0.015).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.47.6.2030-2035.2003

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