The Highly Conserved Stem-Loop II Motif Is Dispensable for SARS-CoV-2-Reference-Cited by-同舟云学术

The Highly Conserved Stem-Loop II Motif Is Dispensable for SARS-CoV-2

Published:2023-06-29 Issue:6 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Jiang Hongbing¹²,Joshi Astha³,Gan Tianyu²,Janowski Andrew B.⁴^ORCID,Fujii Chika²,Bricker Traci L.³,Darling Tamarand L.³,Harastani Houda H.³,Seehra Kuljeet³,Chen Hongwei¹,Tahan Stephen²,Jung Ana⁵,Febles Binita⁵,Blatter Joshua A.²,Handley Scott A.⁵,Parikh Bijal A.⁵^ORCID,Wang David²⁵^ORCID,Boon Adrianus C. M.²³⁵^ORCID

Affiliation:

1. School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China

2. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

3. Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA

4. Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA

5. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA

Abstract

RNA viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), contain functional structures to support virus replication, translation, and evasion of the host antiviral immune response. The 3′ untranslated region of early isolates of SARS-CoV-2 contained a stem-loop II motif (s2m), which is an RNA structural element that is found in many RNA viruses.

Funder

Children’s Discovery Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00635-23

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5. Coronavirus Disease 2019–COVID-19

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