Evolution and Antigenic Advancement of N2 Neuraminidase of Swine Influenza A Viruses Circulating in the United States following Two Separate Introductions from Human Seasonal Viruses-Reference-Cited by-同舟云学术

Evolution and Antigenic Advancement of N2 Neuraminidase of Swine Influenza A Viruses Circulating in the United States following Two Separate Introductions from Human Seasonal Viruses

Published:2021-09-27 Issue:20 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Kaplan Bryan S.¹,Anderson Tavis K.¹^ORCID,Chang Jennifer¹,Santos Jefferson²,Perez Daniel²^ORCID,Lewis Nicola³,Vincent Amy L.¹^ORCID

Affiliation:

1. Virus and Prion Research Unit, National Animal Disease Center, USDA-ARS, Ames, Iowa, USA

2. Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA

3. Department of Pathobiology and Population Sciences, The Royal Veterinary College, University of London, London, Hertfordshire, UK

Abstract

Antibodies inhibiting the neuraminidase (NA) of IAV reduce clinical disease, virus shedding, and transmission, particularly in the absence of neutralizing immunity against hemagglutinin. To understand antibody recognition of the genetically diverse NA in U.S. swine IAV, we characterized the antigenic diversity of N2 from swine and humans.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Agriculture

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00632-21

Reference79 articles.

1. Influenza type A virus neuraminidase does not play a role in viral entry, replication, assembly, or budding

2. Inhibition of Influenza Virus Replication in Tissue Culture by 2-deoxy-2,3-dehydro-N-trifluoroacetylneuraminic acid (FANA): Mechanism of Action