Affiliation:
1. Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Ansan, Republic of Korea
Abstract
SUMMARY
Heterochromatin is the transcriptionally repressed portion of eukaryotic chromatin that maintains a condensed appearance throughout the cell cycle. At sites of ribosomal DNA (rDNA) heterochromatin, epigenetic states contribute to gene silencing and genome stability, which are required for proper chromosome segregation and a normal life span. Here, we focus on recent advances in the epigenetic regulation of rDNA silencing in
Saccharomyces cerevisiae
and in mammals, including regulation by several histone modifications and several protein components associated with the inner nuclear membrane within the nucleolus. Finally, we discuss the perturbations of rDNA epigenetic pathways in regulating cellular aging and in causing various types of diseases.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology,Infectious Diseases
Cited by
68 articles.
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