Lessons Learned and Yet-to-Be Learned on the Importance of RNA Structure in SARS-CoV-2 Replication-Reference-Cited by-同舟云学术

Lessons Learned and Yet-to-Be Learned on the Importance of RNA Structure in SARS-CoV-2 Replication

Published:2022-09-21 Issue:3 Volume:86 Page:
ISSN:1092-2172
Container-title:Microbiology and Molecular Biology Reviews
language:en
Short-container-title:Microbiol Mol Biol Rev

Author:

Bassett Maclean¹²,Salemi Marco¹²^ORCID,Rife Magalis Brittany¹²^ORCID

Affiliation:

1. Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, Florida, USA

2. Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA

Abstract

SARS-CoV-2, the etiological agent responsible for the COVID-19 pandemic, is a member of the virus family Coronaviridae , known for relatively extensive (~30-kb) RNA genomes that not only encode for numerous proteins but are also capable of forming elaborate structures. As highlighted in this review, these structures perform critical functions in various steps of the viral life cycle, ultimately impacting pathogenesis and transmissibility.

Funder

National Science Foundation

Rockefeller Foundation

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology,Infectious Diseases

Link

https://journals.asm.org/doi/pdf/10.1128/mmbr.00057-21

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