Endoplasmic Reticulum Chaperones in Viral Infection: Therapeutic Perspectives

Author:

Kohli Evelyne12ORCID,Causse Sébastien1,Baverel Valentin1,Dubrez Laurence1,Borges-Bonan Natalia1,Demidov Oleg13,Garrido Carmen14

Affiliation:

1. INSERM UMR 1231, Labex LipSTIC, Faculty of Health Sciences, Université de Bourgogne Franche-Comté, Dijon, France

2. University Hospital of Dijon, Dijon, France

3. Laboratory of Molecular Medicine, Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia

4. Center George François Leclerc, Dijon, France

Abstract

Viruses are intracellular parasites that subvert the functions of their host cells to accomplish their infection cycle. The endoplasmic reticulum (ER)-residing chaperone proteins are central for the achievement of different steps of the viral cycle, from entry and replication to assembly and exit. The most abundant ER chaperones are GRP78 (78-kDa glucose-regulated protein), GRP94 (94-kDa glucose-regulated protein), the carbohydrate or lectin-like chaperones calnexin (CNX) and calreticulin (CRT), the protein disulfide isomerases (PDIs) and the DNAJ chaperones.

Funder

Conseil régional de Bourgogne-Franche-Comté

FEDER

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology,Infectious Diseases

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