A Virus Is a Community: Diversity within Negative-Sense RNA Virus Populations

Author:

González Aparicio Lavinia J.12ORCID,López Carolina B.12ORCID,Felt Sébastien A.12ORCID

Affiliation:

1. Department of Molecular Microbiology Washington University School of Medicine, St Louis, Missouri, USA

2. Center for Women's Infectious Disease Research, Washington University School of Medicine, St Louis, Missouri, USA

Abstract

Negative-sense RNA virus populations are composed of diverse viral components that interact to form a community and shape the outcome of virus infections. At the genomic level, RNA virus populations consist not only of a homogeneous population of standard viral genomes but also of an extremely large number of genome variants, termed viral quasispecies, and nonstandard viral genomes, which include copy-back viral genomes, deletion viral genomes, mini viral RNAs, and hypermutated RNAs.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology,Infectious Diseases

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