PSMB1 Inhibits the Replication of Porcine Reproductive and Respiratory Syndrome Virus by Recruiting NBR1 To Degrade Nonstructural Protein 12 by Autophagy-Reference-Cited by-同舟云学术

PSMB1 Inhibits the Replication of Porcine Reproductive and Respiratory Syndrome Virus by Recruiting NBR1 To Degrade Nonstructural Protein 12 by Autophagy

Published:2023-01-31 Issue:1 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Li Liwei¹²,Bai Yuanzhe¹,Zhou Yanjun¹,Jiang Yifeng¹,Tong Wu¹,Li Guoxin¹,Zheng Haihong¹,Gao Fei¹³^ORCID,Tong Guangzhi¹³

Affiliation:

1. Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, People’s Republic of China

2. Shanghai Key Laboratory of Veterinary Biotechnology, Shanghai, People’s Republic of China

3. Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonose, Yangzhou University, Yangzhou, People’s Republic of China

Abstract

PRRS is a major threat to the global pig industry and urgently requires an effective and sustainable control strategy. PRRSV Nsps have important roles in viral RNA synthesis, proteinase activity, induction of replication-associated membrane rearrangements, replicative endoribonuclease activity, determination of virulence, and regulation of host immune response.

Funder

Shanghai Agriculture Applied Technology Development Program

Foundation of Laboratory of Veterinary Biotechnology

Central Public-interest Scientific Institution Basal Research Fund

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01660-22