Discovery and Selection of Hepatitis B Virus-Derived T Cell Epitopes for Global Immunotherapy Based on Viral Indispensability, Conservation, and HLA-Binding Strength

Author:

de Beijer Monique T. A.1,Jansen Diahann T. S. L.1,Dou Yingying1,van Esch Wim J. E.2,Mok Juk Yee2,Maas Mariëlle J. P.2,Brasser Giso2,de Man Robert A.1,Woltman Andrea M.1,Buschow Sonja I.1

Affiliation:

1. Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands

2. Sanquin, Amsterdam, the Netherlands

Abstract

Multiple HBV-derived T cell epitopes have been reported, which can be useful in a therapeutic vaccination strategy. However, these epitopes are largely restricted to HLA-A*02, which is not dominantly expressed in populations with high HBV prevalence. Thus, current epitopes are falling short in the development of a global immunotherapeutic approach. Therefore, we aimed to identify novel epitopes for 6 HLA supertypes most prevalent in the infected population. Moreover, established epitopes might not all be equally effective as they can be subject to different levels of immune escape. It is therefore important to identify targets that are crucial in viral replication and conserved in the majority of the infected population. Here, we applied a stringent selection procedure to compose a combined overview of existing and novel HBV-derived T cell epitopes most promising for viral eradication. This set of T cell epitopes now lays the basis for the development of globally effective HBV antigen-specific immunotherapies.

Funder

Health Holland, Top Sector Life Sciences & Health

ISA Pharmaceuticals B.V.

KWF Kankerbestrijding

Maag Lever Darm Stichting

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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