Murine Model for the Study of Influenza D Virus-Reference-Cited by-同舟云学术

Murine Model for the Study of Influenza D Virus

Published:2020-01-31 Issue:4 Volume:94 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Oliva J.¹,Mettier J.²,Sedano L.²,Delverdier M.¹,Bourgès-Abella N.³,Hause B.⁴,Loupias J.¹,Pardo I.³,Bleuart C.³,Bordignon P. J.⁵,Meunier E.⁵,Le Goffic R.²^ORCID,Meyer G.¹,Ducatez M. F.¹

Affiliation:

1. IHAP, Université de Toulouse, INRA, ENVT, Toulouse, France

2. Unité de Virologie et Immunologie Moléculaires (UR0892), INRA, Jouy-en-Josas, France

3. Université de Toulouse, ENVT, Toulouse, France

4. Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA

5. Institute of Pharmacology and Structural Biology, CNRS, Toulouse, France

Abstract

Influenza D virus (IDV), a new genus of Orthomyxoviridae family, presents a large host range and a worldwide circulation. The pathogenicity of this virus has been studied in the calf model. The mouse model is frequently used to enable a first assessment of a pathogen ’ s fitness, replication, and pathogenesis for influenza A and B viruses. We showed that DBA/2 mice are a relevant in vivo model for the study of IDV replication. This model will allow for rapid IDV fitness and replication evaluation and will enable phenotypic comparisons between isolated viruses. It will also allow for a better understanding of the immune response induced after IDV infection.

Funder

ANR

Region Ile de France

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01662-19

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2. Characterization of a Novel Influenza Virus in Cattle and Swine: Proposal for a New Genus in the Orthomyxoviridae Family