Genetic Features of the Widespread Plasmid Coding for the Carbapenemase OXA-48

Abstract

ABSTRACTComplete sequencing of plasmid pOXA-48a carrying theblaOXA-48gene from aKlebsiella pneumoniaeisolate was performed. Its backbone corresponded to that of an IncL/M-type plasmid, in which theblaOXA-48gene had been integrated through the acquisition of the Tn1999composite transposon without any other antibiotic resistance gene. Molecular epidemiology using a collection of international OXA-48 producers revealed the wide diffusion of pOXA-48a or closely related plasmids.