Suppression of Chlamydial Pathogenicity by Nonspecific CD8 + T Lymphocytes-Reference-Cited by-同舟云学术

Suppression of Chlamydial Pathogenicity by Nonspecific CD8 + T Lymphocytes

Published:2020-09-18 Issue:10 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Xie Lingxiang¹²,He Conghui¹,Chen Jianlin²,Tang Lingli²,Zhou Zhiguang²,Zhong Guangming¹^ORCID

Affiliation:

1. Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

2. The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

Abstract

Chlamydia trachomatis , a leading infectious cause of tubal infertility, induces upper genital tract pathology, such as hydrosalpinx, which can be modeled with Chlamydia muridarum infection in mice. Following C. muridarum inoculation, wild-type mice develop robust hydrosalpinx, but OT1 mice fail to do so because their T cell receptors are engineered to recognize a single ovalbumin epitope (OVA 457-462 ). These observations have demonstrated a critical role of Chlamydia -specific T cells in chlamydial pathogenicity.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00315-20

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