c-di-AMP-Regulated K + Importer KtrAB Affects Biofilm Formation, Stress Response, and SpeB Expression in Streptococcus pyogenes

Abstract

The second messenger cyclic di-AMP (c-di-AMP) controls biofilm formation, stress response, and virulence in Streptococcus pyogenes . The deletion of the c-di-AMP synthase gene, dacA , results in pleiotropic effects including reduced expression of the secreted protease SpeB.