Affiliation:
1. Nuffield Department of Clinical Laboratory Sciences
2. Department of Pediatrics
3. Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
Abstract
ABSTRACT
Nasal carriage of
Staphylococcus aureus
is a major risk factor for invasive
S. aureus
disease. The aim of this study was to define factors associated with carriage. We conducted a prospective, longitudinal community-based study of infants and their mothers for a period of 6 months following delivery. The epidemiology of carriage was examined for 100 infant-mother pairs. Infant carriage varied significantly with age, falling from 40 to 50% during the first 8 weeks to 21% by 6 months. Determinants of infant
S. aureus
carriage included maternal carriage, breastfeeding, and number of siblings. Bacterial typing of
S. aureus
was performed by pulsed-field gel electrophoresis and multilocus sequence typing. The majority of individuals carried a single strain of
S. aureus
over time, and the mother was the usual source for colonizing isolates in infants. The effect of other components of the normal nasal flora on the development of
S. aureus
carriage was examined in 157 consecutive infants. Negative associations (putative bacterial interference) between
S. aureus
and other species occurred early in infancy but were not sustained. An increasing antistaphylococcal effect observed over time was not attributable to bacterial interference.
S. aureus
carriage in infants is likely to be determined by a combination of host, environmental, and bacterial factors, but bacterial interference does not appear to be an ultimate determinant of carrier status.
Publisher
American Society for Microbiology
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