Author:
Kesado T,Watanabe K,Asahi Y,Isono M,Ueno K
Abstract
The susceptibilities of 462 clinical anaerobic bacterial isolates to N-formimidoyl thienamycin and 16 other currently available and investigational antibiotics were determined by the agar dilution technique. N-Formimidoyl thienamycin was significantly more active than the reference antibiotics against most organisms tested, especially Bacteroides sp., including clindamycin-resistant strains. All 462 isolates were inhibited by 4 micrograms of N-formimidoyl thienamycin per ml, and no resistant strains were found in the species tested. N-Formimidoyl thienamycin was less active (i.e., had a higher 50% minimal inhibitory concentration) against Fusobacterium sp. than clindamycin, SM-1652, and piperacillin, and less active against Clostridium difficile than metronidazole, but was equally active or more active than the other reference antibiotics tested.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference8 articles.
1. In vitro activity of N-formimidoyl thienamycin (MK0787), a crystalline derivative of thienamycin;Horadam V. W.;Antimicrob. Agents Chemother.,1980
2. Antibacterial activities of a new stabilized thienamycin, N-formimidoyl thienamycin, in comparison with other antibiotics;Kesado T.;Antimicrob. Agents Chemother.,1980
3. MK0787 (N-formimidoyl thienamycin): evaluation of in vitro and in vivo activities;Kropp H.;Antimicrob. Agents Chemother.,1980
4. In vitro activity of N-formimidoyl thienamycin (MK0787) against resistant strains of Pseudomonas aeruginosa, Staphylococcus epidermidis, Serratia marcescens, and Enterococcus spp;Livinston W. K.;Antimicrob. Agents Chemother.,1981
5. N-Formimidoyl thienamycin (MK0787): in vitro study;Shadomy S.;Antimicrob. Agents Chemother.,1981
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