Antibody Responses to Asian and American Genotypes of Dengue 2 Virus in Immunized Mice-Reference-Cited by-同舟云学术

Antibody Responses to Asian and American Genotypes of Dengue 2 Virus in Immunized Mice

Published:2005-02 Issue:2 Volume:12 Page:361-362
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Bernardo Lidice¹,Yndart Adriana¹,Vázquez Susana¹,Morier Luis¹,Guzmán María G.¹

Affiliation:

1. Virology Department, PAHO/WHO Collaborating Center for Viral Diseases, “Pedro Kourí” Tropical Medicine Institute, Autopista Novia del Mediodía, Havana, Cuba

Abstract

ABSTRACT The possibility of a correlation between dengue virus genotype groups and disease severity is currently under discussion. The objective of this investigation was to identify any immunogenic difference between the American and Asian dengue 2 virus genotypes through the study of antibody development (virus-binding immunoglobulin G and neutralizing antibodies) in mice. Differences in the neutralization pattern between the strains studied were observed, suggesting the presence of slight antigenic variations among them. The lack of recognition of one of the Asian genotype strains was remarkable.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CDLI.12.2.361-362.2005

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