Studies on the Nucleic Acid Sequences of Kirsten Sarcoma Virus: a Model for Formation of a Mammalian RNA-Containing Sarcoma Virus-Reference-Cited by-同舟云学术

Studies on the Nucleic Acid Sequences of Kirsten Sarcoma Virus: a Model for Formation of a Mammalian RNA-Containing Sarcoma Virus

Published:1973-09 Issue:3 Volume:12 Page:458-463
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Scolnick Edward M.¹²,Rands Elaine¹²,Williams David¹²,Parks Wade P.¹²

Affiliation:

1. Viral Lymphoma and Leukemia Branch, Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryland 20014

2. Meloy Laboratories, Rockville, Maryland 20850

Abstract

The genetic information contained in the Kirsten and Moloney strains of mammalian RNA-containing sarcoma viruses has been analyzed by RNA · 3 H-DNA hybridization. Kirsten sarcoma virus has been found to possess two distinct sets of nucleic acid sequences. One set of sequences is contained in murine type C helper virus, and the other set is contained in rat type C helper virus. Moloney sarcoma virus contains sequences of murine type C helper virus but not of rat type C helper virus. The results indicate that Kirsten sarcoma virus arose through a process of recombination between Kirsten murine leukemia virus and nucleic acid sequences found in rat cells. A model is suggested for the formation of transforming type C viruses involving the transduction of oncogenic information.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.12.3.458-463.1973

Reference18 articles.

1. Characterization of murine sarcoma virus (Kirsten) transformation of mouse and human cells;Aaronson S. A.;J. Gen. Virol.,1971

2. Induction of mutations in an RNA tumor virus by an analogue of a DNA precursor;Bader J. P.;Nature N. Biol.,1971

3. Isolation of murine sarcoma virus transformed mouse cells which are negative for leukemia virus from agar suspension culture;Bassin R H;Int. J. Cancer,1970

4. RNA in mammalian sarcoma virus transformed nonproducer cells homologous to murine leukemia virus RNA;Benveniste R.;Virology,1973

5. Difference between the ribonucleic acids of transforming and non-transforming avian tumor viruses;Duesberg P. H.;Proc. Nat. Acad. Sci. U.S.A.,1970

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