Clinical Laboratory Tests Used To Aid in Diagnosis of Human Prion Disease-Reference-Cited by-同舟云学术

Clinical Laboratory Tests Used To Aid in Diagnosis of Human Prion Disease

Published:2019-10 Issue:10 Volume:57 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Connor Allyson¹,Wang Han¹,Appleby Brian S.¹²³,Rhoads Daniel D.³

Affiliation:

1. Department of Neurology, University Hospitals Cleveland Medical Center/Case Western Reserve University, Cleveland, Ohio, USA

2. Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA

3. National Prion Disease Pathology Surveillance Center, Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA

Abstract

Prion diseases are a group of rapidly progressive and always fatal neurodegenerative disorders caused by misfolded prion protein in the brain. Although autopsy remains the gold-standard diagnostic tool, antemortem laboratory testing can be performed to aid in the diagnosis of prion disease. This review is meant to help laboratory directors and physicians in their interpretation of test results.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00769-19

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