Cross-Reactivity Using Chimeric Trypanosoma cruzi Antigens: Diagnostic Performance in Settings Where Chagas Disease and American Cutaneous or Visceral Leishmaniasis Are Coendemic-Reference-Cited by-同舟云学术

Cross-Reactivity Using Chimeric Trypanosoma cruzi Antigens: Diagnostic Performance in Settings Where Chagas Disease and American Cutaneous or Visceral Leishmaniasis Are Coendemic

Published:2019-08 Issue:8 Volume:57 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Daltro Ramona Tavares¹,Leony Leonardo Maia¹,Freitas Natália Erdens Maron¹,Silva Ângelo Antônio Oliveira¹,Santos Emily Ferreira¹,Del-Rei Rodrigo Pimenta²,Brito Maria Edileuza Felinto³,Brandão-Filho Sinval Pinto³,Gomes Yara Miranda³,Silva Marcelo Sousa⁴⁵,Donato Silvia Tavares⁴,Jeronimo Selma Maria Bezerra⁴,Monteiro Gloria Regina de Góis⁴,Carvalho Lucas Pedreira¹⁶,Magalhães Andréa Santos⁶,Zanchin Nilson Ivo Tonin⁷,Celedon Paola Alejandra Fiorani⁸,Santos Fred Luciano Neves¹^ORCID

Affiliation:

1. Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil

2. Faculty of Technology and Sciences of Bahia, Salvador, Bahia, Brazil

3. Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, Pernambuco, Brazil

4. Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil

5. Institute of Hygiene and Tropical Medicine, Lisbon, Portugal

6. Federal University of Bahia, Salvador, Bahia, Brazil

7. Carlos Chagas Institute, Oswaldo Cruz Foundation, Curitiba, Paraná, Brazil

8. Molecular Biology Institute of Paraná, Curitiba, Paraná, Brazil

Abstract

Chimeric T. cruzi antigens have been proposed as a diagnostic tool for chronic Chagas disease (CD) in both settings where Chagas disease is endemic and those where it is not endemic. Antibody response varies in accordance to each T. cruzi strain, presenting challenges to the use of antigens lacking demonstrated cross-reactivity with Leishmania spp.

Funder

Internal Research Support Program

Coordination of Superior Level Staff Improvement - CAPES

National Council for Scientific and Technological Development - CNPq

Araucária Foundation

Research Support Foundation of the State of Bahia

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00762-19

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