A Multiplexed Serologic Test for Diagnosis of Lyme Disease for Point-of-Care Use-Reference-Cited by-同舟云学术

A Multiplexed Serologic Test for Diagnosis of Lyme Disease for Point-of-Care Use

Published:2019-12 Issue:12 Volume:57 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Arumugam Siddarth¹,Nayak Samiksha¹,Williams Taylor²,di Santa Maria Francesco Serra¹,Guedes Mariana Soares²³,Chaves Rodrigo Cotrim¹,Linder Vincent⁴,Marques Adriana R.⁵^ORCID,Horn Elizabeth J.⁶,Wong Susan J.⁷,Sia Samuel K.¹,Gomes-Solecki Maria²³^ORCID

Affiliation:

1. Department of Biomedical Engineering, Columbia University, New York, New York, USA

2. Immuno Technologies Inc., Memphis, Tennessee, USA

3. Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USA

4. Opko Diagnostics LLC, Woburn, Massachusetts, USA

5. Lyme Disease Studies Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

6. Lyme Disease Biobank, Portland, Oregon, USA

7. Wadsworth Center, New York State Department of Health, Axelrod Institute, Albany, New York, USA

Abstract

Single multiplexed assays could replace the standard 2-tiered (STT) algorithm recommended for the laboratory diagnosis of Lyme disease if they perform with a specificity and a sensitivity superior or equal to those of the STT algorithm.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01142-19

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3. Incidence of Clinician-Diagnosed Lyme Disease, United States, 2005–2010