Early Growth Response 1 Deficiency Protects the Host against Pseudomonas aeruginosa Lung Infection-Reference-Cited by-同舟云学术

Early Growth Response 1 Deficiency Protects the Host against Pseudomonas aeruginosa Lung Infection

Published:2019-12-17 Issue:1 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Pang Zheng¹,Raudonis Renee²,McCormick Craig²^ORCID,Cheng Zhenyu¹²^ORCID

Affiliation:

1. Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada

2. Department of Microbiology & Immunology, Dalhousie University, Halifax, Nova Scotia, Canada

Abstract

Pseudomonas aeruginosa is an opportunistic pathogen that is a common cause of nosocomial infections. The molecular mechanisms governing immune responses to P. aeruginosa infection remain incompletely defined. Early growth response 1 (Egr-1) is a zinc-finger transcription factor that controls inflammatory responses. Here, we characterized the role of Egr-1 in host defense against P. aeruginosa infection in a mouse model of acute bacterial pneumonia.

Funder

Cystic Fibrosis Canada

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Gouvernement du Canada | Canadian Institutes of Health Research

Canada Foundation for Innovation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00678-19

Reference77 articles.