Lipidation of <i>Haemophilus influenzae</i> Antigens P6 and OMP26 Improves Immunogenicity and Protection against Nasopharyngeal Colonization and Ear Infection-Reference-Cited by-同舟云学术

Lipidation of Haemophilus influenzae Antigens P6 and OMP26 Improves Immunogenicity and Protection against Nasopharyngeal Colonization and Ear Infection

Published:2022-05-19 Issue:5 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Kaur Ravinder¹^ORCID,Pichichero Michael¹

Affiliation:

1. Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester, New York, USA

Abstract

Nontypeable Haemophilus influenzae (NTHi) causes respiratory infections that lead to high morbidity and mortality worldwide, encouraging development of effective vaccines. To achieve a protective impact on nasopharyngeal (NP) colonization by NTHi, enhanced immunogenicity beyond that achievable with recombinant-protein antigens is likely to be necessary.

Funder

Rochester Regional Health

HHS | NIH | National Institute on Deafness and Other Communication Disorders

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00678-21

Reference57 articles.

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