Acid Ceramidase Rescues Cystic Fibrosis Mice from Pulmonary Infections-Reference-Cited by-同舟云学术

Acid Ceramidase Rescues Cystic Fibrosis Mice from Pulmonary Infections

Published:2021-01-19 Issue:2 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Becker Katrin Anne¹,Verhaegh Rabea¹,Verhasselt Hedda-Luise²,Keitsch Simone¹,Soddemann Matthias¹,Wilker Barbara¹,Wilson Gregory C.³,Buer Jan²,Ahmad Syed A.³,Edwards Michael J.³,Gulbins Erich¹³^ORCID

Affiliation:

1. Institute of Molecular Biology, University of Duisburg-Essen, Essen, Germany

2. Institute of Medical Microbiology, Medical School Essen, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

3. Department of Surgery, University of Cincinnati Medical School, Cincinnati, Ohio, USA

Abstract

Previous studies have shown that sphingosine kills a variety of pathogenic bacteria, including Pseudomonas aeruginosa and Staphylococcus aureus . Sphingosine concentrations are decreased in airway epithelial cells of cystic fibrosis (CF) mice, and this defect has been linked to the infection susceptibility of these mice. Here, we tested whether the genetic overexpression of acid ceramidase rescues cystic fibrosis mice from pulmonary infections with P. aeruginosa .

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00677-20

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